doi: 10.1016/0002-9378(75)90470-6.
Endocrine influences on pulmonary maturation and the lecithin/sphingomyelin ratio in the fetal baboon
- PMID: 1038322
- DOI: 10.1016/0002-9378(75)90470-6
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Endocrine influences on pulmonary maturation and the lecithin/sphingomyelin ratio in the fetal baboon
Am J Obstet Gynecol.
.
Abstract
By utilizing the baboon model system, preliminary data indicate that intra-amniotic dexamethasone caused an increase in the L/S ratio. Metopirone 11-betahydroxylase inhibition prevented the expected increase in the L/S ratio without influencing pulmonary distensibility, stability on deflation, or lung mince minimal surface tension. Infants born at term to Metopirone-treated baboons were free of pulmonary distress and survived to adolescence.
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