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Comment
. 1999 Jul;48(1):9-13.
doi: 10.1046/j.1365-2125.1999.00971.x.

Target concentration intervention: beyond Y2K

N H Holford  1
Affiliations
Comment

Target concentration intervention: beyond Y2K

N H Holford. Br J Clin Pharmacol. 1999 Jul.

Abstract

Target concentration intervention (TCI) is proposed as an alternative conceptual strategy to therapeutic drug monitoring (TDM). It is argued that the idea of a therapeutic range has limited the interpretation of measured drug concentrations and diminished the anticipated clinical benefit to patients by use of an oversimplified pharmacodynamic model. TCI on the other hand embraces pharmacokinetic and pharmacodynamic concepts and uses the idea of a target effect and associated target concentration to make rational individual dose decisions.

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