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. 1999 May-Jun;16(3):222-7.
doi: 10.1046/j.1525-1470.1999.00065.x.

Blue rubber bleb nevus (Bean syndrome): evolution of four cases and clinical response to pharmacologic agents

M D Boente  1 , M R Cordisco, M D Frontini, R A Asial
Affiliations

Blue rubber bleb nevus (Bean syndrome): evolution of four cases and clinical response to pharmacologic agents

M D Boente et al. Pediatr Dermatol. 1999 May-Jun.

Abstract

Blue rubber bleb nevus (BRBN) syndrome is a rare disorder characterized by distinctive cutaneous and gastrointestinal vascular malformations. The latter may lead to bleeding complications. We followed four affected children for at least 5 years. The evolution of their disease and the value of pharmacologic agents (steroids, interferon) in the management of some of these patients are discussed.

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