Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Jun 7;9(11):1625-30.
doi: 10.1016/s0960-894x(99)00250-4.

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

G W Muller  1 , R Chen, S Y Huang, L G Corral, L M Wong, R T Patterson, Y Chen, G Kaplan, D I Stirling
Affiliations

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

G W Muller et al. Bioorg Med Chem Lett. .

Abstract

Thalidomide, (1), is a known inhibitor of TNF-alpha release in LPS stimulated human PBMC. Herein we describe the TNF-alpha inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-alpha release in LPS stimulated human PBMC.

PubMed Disclaimer

MeSH terms

LinkOut - more resources