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. 1999 Jul;43(7):1764-6.
doi: 10.1128/AAC.43.7.1764.

pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia

H J Marttila  1 , M Marjamäki, E Vyshnevskaya, B I Vyshnevskiy, T F Otten, A V Vasilyef, M K Viljanen
Affiliations

pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia

H J Marttila et al. Antimicrob Agents Chemother. 1999 Jul.

Abstract

Thirty-six pyrazinamide-resistant and eight pyrazinamide-susceptible Mycobacterium tuberculosis isolates from Russia were analyzed for their pncA mutations. Thirty-one (86.1%) of the resistant isolates had a mutation either in pncA or upstream of the gene. Twenty of the 23 different mutations found in this study had not been described earlier. pncA genotype correlated well with pyrazinamidase activity and BACTEC 460 susceptibility test results.

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Figures

FIG. 1
FIG. 1
GelCompar dendrogram showing the interrelationships of PZA-resistant M. tuberculosis isolates with either unmutated pncA and its putative regulatory region or a −11 A-to-G mutation in the putative pncA-regulatory region.
See this image and copyright information in PMC

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