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Review
. 1999 Jul;7(7):281-91.
doi: 10.1016/s0966-842x(99)01539-5.

Variation and evolution of the citric-acid cycle: a genomic perspective

M A Huynen  1 , T Dandekar, P Bork
Affiliations
Review

Variation and evolution of the citric-acid cycle: a genomic perspective

M A Huynen et al. Trends Microbiol. 1999 Jul.

Abstract

The presence of genes encoding enzymes involved in the citric-acid cycle has been studied in 19 completely sequenced genomes. In the majority of species, the cycle appears to be incomplete or absent. Several distinct, incomplete cycles reflect adaptations to different environments. Their distribution over the phylogenetic tree hints at precursors in the evolution of the citric-acid cycle.

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