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. 1999 Aug;180(2):505-8.
doi: 10.1086/314903.

Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong, 1997

A W Mounts  1 , H Kwong, H S Izurieta, Y Ho, T Au, M Lee, C Buxton Bridges, S W Williams, K H Mak, J M Katz, W W Thompson, N J Cox, K Fukuda
Affiliations

Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong, 1997

A W Mounts et al. J Infect Dis. 1999 Aug.

Abstract

In May 1997, a 3-year-old boy in Hong Kong died of a respiratory illness related to influenza A (H5N1) virus infection, the first known human case of disease from this virus. An additional 17 cases followed in November and December. A case-control study of 15 of these patients hospitalized for influenza A (H5N1) disease was conducted using controls matched by age, sex, and neighborhood to determine risk factors for disease. Exposure to live poultry (by visiting either a retail poultry stall or a market selling live poultry) in the week before illness began was significantly associated with H5N1 disease (64% of cases vs. 29% of controls, odds ratio, 4.5, P=.045). By contrast, travel, eating or preparing poultry products, recent exposure to persons with respiratory illness, including persons with known influenza A (H5N1) infection, were not associated with H5N1 disease.

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