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Review
. 1999 Feb;187(3):272-8.
doi: 10.1002/(SICI)1096-9896(199902)187:3<272::AID-PATH265>3.0.CO;2-2.

The transition from hyperplasia to invasive carcinoma of the breast

S R Lakhani  1
Affiliations
Review

The transition from hyperplasia to invasive carcinoma of the breast

S R Lakhani. J Pathol. 1999 Feb.

Abstract

The multistep model of carcinogenesis in the breast suggests a transition from normal epithelium to invasive carcinoma via non-atypical and atypical hyperplasia and in situ carcinoma. Within the breast, these proliferations are heterogeneous in their cytological and architectural characteristics. This review considers the evidence supporting a precursor role for these preinvasive lesions.

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