Editorial
doi: 10.1002/(SICI)1096-9896(199904)187:5<499::AID-PATH309>3.0.CO;2-B.
Serrated adenoma and colorectal cancer
- PMID: 10398112
- DOI: 10.1002/(SICI)1096-9896(199904)187:5<499::AID-PATH309>3.0.CO;2-B
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Editorial
Serrated adenoma and colorectal cancer
J Pathol.
1999 Apr.
Abstract
Hyperplastic polyps and serrated adenomas of the colorectum show mixed gastrointestinal differentiation, expressing both gastric (M1 or MUC5AC) and intestinal (MUC2) mucins. They also share the phenotype of mild DNA microsatellite instability (MSI-L). Recent findings of clonal genetic changes within hyperplastic polyps fit with a pathway of serrated neoplasia, perhaps culminating in the subset of colorectal cancer characterized by the mild mutator phenotype.
Copyright 1999 John Wiley & Sons, Ltd.
Comment on
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'Serrated' adenoma of the colorectum, with reference to its gastric differentiation and its malignant potential.J Pathol. 1999 Apr;187(5):511-7. doi: 10.1002/(SICI)1096-9896(199904)187:5<511::AID-PATH308>3.0.CO;2-8. J Pathol. 1999. PMID: 10398114
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