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. 1999 May;7(5):715-21.
doi: 10.1016/s0968-0896(99)00023-1.

An in vitro investigation into conformational aspects of gabapentin

J S Bryans  1 , D C Horwell, G S Ratcliffe, J M Receveur, J R Rubin
Affiliations

An in vitro investigation into conformational aspects of gabapentin

J S Bryans et al. Bioorg Med Chem. 1999 May.

Abstract

Conformational analysis of constrained cyclohexane systems was pioneered fifty years ago by Barton and Hassel. We now report an investigation based on a conformational analysis of a number of novel cyclohexane based Gabapentin analogues coupled with their in vitro evaluation at the Gabapentin binding site. These data are used to propose a possible binding conformation for Gabapentin.

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