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. 1978;43(2):153-60.
doi: 10.1007/BF01579074.

Endocrine aspects of bromocriptine therapy in Parkinsonism

K M Shaw, A J Lees, S Franks, P Daggett, B D Thompson, G M Stern

Endocrine aspects of bromocriptine therapy in Parkinsonism

K M Shaw et al. J Neural Transm. 1978.

Abstract

Plasma growth hormone (GH) concentrations in Parkinsonian patients following 3 months optimum therapy with bromocriptine showed no significant change from pretreatment values, whilst plasma prolactin concentrations were uniformly suppressed. Pretreatment GH and prolactin levels were unrelated to clinical disability, and no correlation between hormonal changes and therapeutic response was found. These results suggest the presence of different dopaminergic receptor mechanisms for GH and prolactin release as well as between the extrapyramidal and neuroendocrine systems.

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