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. 1999 Jul;156(7):1091-3.
doi: 10.1176/ajp.156.7.1091.

Subgenual cingulate cortex volume in first-episode psychosis

Y Hirayasu  1 , M E Shenton, D F Salisbury, J S Kwon, C G Wible, I A Fischer, D Yurgelun-Todd, C Zarate, R Kikinis, F A Jolesz, R W McCarley
Affiliations

Subgenual cingulate cortex volume in first-episode psychosis

Y Hirayasu et al. Am J Psychiatry. 1999 Jul.

Abstract

Objective: Gray matter volume and glucose utilization have been reported to be reduced in the left subgenual cingulate of subjects with familial bipolar or unipolar depression. It is unclear whether these findings are secondary to recurrent illness or are part of a familial/genetic syndrome. The authors' goal was to clarify these findings.

Method: Volumetric analyses were performed by using magnetic resonance imaging in 41 patients experiencing their first episode of affective disorder or schizophrenia and in 20 normal comparison subjects.

Results: The left subgenual cingulate volume of the patients with affective disorder who had a family history of affective disorder was smaller than that of patients with affective disorder with no family history of the illness and the normal comparison subjects. Patients with schizophrenia did not differ from comparison subjects in left subgenual cingulate volume.

Conclusions: Left subgenual cingulate abnormalities are present at first hospitalization for psychotic affective disorder in patients who have a family history of affective disorder.

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Figures

FIGURE 1
FIGURE 1. Absolute Volumes of the Subgenual Cingulate Cortex in Patients Experiencing Their First Episode of Affective Disorder or Schizophrenia and Normal Comparison Subjectsa
aHorizontal lines represent means. The mean left subgenual cingulate volume for patients with affective disorder who had a family history of affective disorder was 181 mm3 (SD=45); for patients with affective disorder who had no family history of the disorder, mean=239 mm3 (SD=43); for patients with schizophrenia, mean= 184 mm3 (SD=59); for normal comparison subjects, mean=226 mm3 (SD=51). The mean right subgenual cingulate volume for patients with affective disorder who had a family history of affective disorder was 225 mm3 (SD=73); for patients with affective disorder who had no family history of the disorder, mean=277 mm3 (SD= 89); for patients with schizophrenia, mean=232 mm3 (SD=105); for normal comparison subjects, mean=280 mm3 (SD=87).
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