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. 1999 Jun;22(3):309-12.
doi: 10.1007/BF02976369.

Inhibition of aromatase activity by flavonoids

H J Jeong  1 , Y G Shin, I H Kim, J M Pezzuto
Affiliations

Inhibition of aromatase activity by flavonoids

H J Jeong et al. Arch Pharm Res. 1999 Jun.

Abstract

In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 microg/mL), chrysin (IC50: 1.1 microg/mL), and hesperetin (IC50: 1.0 microg/mL).

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