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. 1999 Jul;6(7):672-82.
doi: 10.1038/10728.

A protein taxonomy based on secondary structure

T Przytycka  1 , R Aurora, G D Rose
Affiliations

A protein taxonomy based on secondary structure

T Przytycka et al. Nat Struct Biol. 1999 Jul.

Abstract

Does a protein's secondary structure determine its three-dimensional fold? This question is tested directly by analyzing proteins of known structure and constructing a taxonomy based solely on secondary structure. The taxonomy is generated automatically, and it takes the form of a tree in which proteins with similar secondary structure occupy neighboring leaves. Our tree is largely in agreement with results from the structural classification of proteins (SCOP), a multidimensional classification based on homologous sequences, full three-dimensional structure, information about chemistry and evolution, and human judgment. Our findings suggest a simple mechanism of protein evolution.

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