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. 1999 Aug;37(8):2717-8.
doi: 10.1128/JCM.37.8.2717-2718.1999.

Typing of clinical herpes simplex virus type 1 and type 2 isolates with monoclonal antibodies

J A Liljeqvist  1 , B Svennerholm, T Bergström
Affiliations

Typing of clinical herpes simplex virus type 1 and type 2 isolates with monoclonal antibodies

J A Liljeqvist et al. J Clin Microbiol. 1999 Aug.

Erratum in

  • J Clin Microbiol 1999 Nov;37(11):3788

Abstract

The purpose of this study was to evaluate the performance of a herpes simplex virus (HSV) type 1-specific anti-glycoprotein C-1 monoclonal antibody (MAb) and a type 2-specific anti-glycoprotein G-2 MAb for typing of 2,400 clinical HSV-1 isolates and 2,400 clinical HSV-2 isolates, respectively, using an enzyme immunoassay. The anti-HSV-1 MAb showed sensitivity and specificity of 100%, and the anti-HSV-2 MAb showed a sensitivity of 99.46% and 100% specificity, indicating that these MAbs are suitable for typing of clinical HSV isolates.

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References

    1. Ashley R L. Laboratory techniques in the diagnosis of herpes simplex infection. Genitourin Med. 1993;69:174–183. - PMC - PubMed
    1. Bergström T, Sjögren-Jansson E, Jeansson S, Lycke E. Mapping neuroinvasiveness of the herpes simplex virus type 1 encephalitis-inducing strain 2762 by the use of monoclonal antibodies. Mol Cell Probes. 1992;6:41–49. - PMC - PubMed
    1. Dragavon J, Peterson E, Ashley R, Lafferty W, Corey L. Routine typing of herpes simplex virus isolates. Diagn Microbiol Infect Dis. 1985;3:269–270. - PubMed
    1. Johnston S L G, Wellens K. Comparative evaluation of four commercially available monoclonal antibodies for culture confirmation of herpes simplex virus infection. J Clin Microbiol. 1992;30:1874–1875. - PMC - PubMed
    1. Liljeqvist J-Å, Trybala E, Svennerholm B, Jeansson S, Sjögren-Jansson E, Bergström T. Localization of type-specific epitopes of herpes simplex virus type 2 glycoprotein G recognized by human and mouse antibodies. J Gen Virol. 1998;79:1215–1224. - PubMed

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