Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Jul;26(7):1518-26.

Defective proliferative response of T lymphocytes from patients with inactive systemic lupus erythematosus

M P Hernández-Fuentes  1 , E Reyes, A Prieto, A Zea, L Villa, A Sánchez-Atrio, F Esquivel, M Alvarez-Mon
Affiliations
  • PMID: 10405939

Defective proliferative response of T lymphocytes from patients with inactive systemic lupus erythematosus

M P Hernández-Fuentes et al. J Rheumatol. 1999 Jul.

Abstract

Objective: To further define the pattern of alterations in the activation and apoptosis of T lymphocytes in patients with inactive systemic lupus erythematosus (SLE) through analysis of a large series of individuals.

Methods: We isolated CD2+ peripheral blood lymphocytes (PBL) from 41 patients with inactive SLE and analyzed their proliferative and apoptotic responses to polyclonal activation.

Results: In 19 of 41 (47%) patients, a low proliferative response to polyclonal mitogens was found. This defective response was inversely associated with an increased apoptotic response and increased expression of CD95 and CD45RO antigens.

Conclusion: We found that 2 groups of patients with inactive disease can be defined according to the functional behavior of their T lymphocytes, as defined by the proliferative and apoptotic responses to mitogenic signals.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources