doi: 10.1006/geno.1999.5860.
MLL2: A new mammalian member of the trx/MLL family of genes
Affiliations
- PMID: 10409430
- DOI: 10.1006/geno.1999.5860
Item in Clipboard
MLL2: A new mammalian member of the trx/MLL family of genes
Genomics.
.
Abstract
We have identified a gene at chromosome band 19q13.1, which is closely related to MLL. MLL is located in a region of chromosome 11q23 that has partial synteny with chromosome 19q. We have named this gene at 19q13.1, MLL2. MLL2 encodes a protein that exhibits a high level of similarity to MLL over several important protein domains. MLL2 is also ubiquitously expressed among adult human tissues, as is MLL. MLL is a homologue of the Drosophila gene trithorax (trx), which encodes a regulator of homeotic gene expression. MLL is involved in chromosome rearrangements associated with leukemia in mammals. However, no MLL2 rearrangements associated with leukemia have been recorded.
Copyright 1999 Academic Press.
Similar articles
-
MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.Gene. 2002 Feb 6;284(1-2):73-81. doi: 10.1016/s0378-1119(02)00392-x. Gene. 2002. PMID: 11891048
-
Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects.Cancer Detect Prev. 2001;25(5):454-69. Cancer Detect Prev. 2001. PMID: 11718452
-
Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.Oncogene. 1997 Jul 31;15(5):549-60. doi: 10.1038/sj.onc.1201211. Oncogene. 1997. PMID: 9247308
-
11q23 rearrangements in acute leukemia.Leukemia. 1996 Jan;10(1):74-82. Leukemia. 1996. PMID: 8558942 Review.
-
Rearrangements involving chromosome band 11Q23 in acute leukaemia.Semin Cancer Biol. 1993 Dec;4(6):377-85. Semin Cancer Biol. 1993. PMID: 8142623 Review.
Cited by
-
Histone H3 lysine 4 (H3K4) methylation in development and differentiation.Dev Biol. 2010 Mar 15;339(2):240-9. doi: 10.1016/j.ydbio.2009.08.017. Epub 2009 Aug 21. Dev Biol. 2010. PMID: 19703438 Free PMC article. Review.
-
Common chromatin structures at breakpoint cluster regions may lead to chromosomal translocations found in chronic and acute leukemias.Hum Genet. 2006 Jun;119(5):479-95. doi: 10.1007/s00439-006-0146-9. Epub 2006 Mar 30. Hum Genet. 2006. PMID: 16572268
-
Reprogramming of the epigenome in neurodevelopmental disorders.Crit Rev Biochem Mol Biol. 2022 Feb;57(1):73-112. doi: 10.1080/10409238.2021.1979457. Epub 2021 Oct 2. Crit Rev Biochem Mol Biol. 2022. PMID: 34601997 Free PMC article. Review.
-
Structure, Activity and Function of the MLL2 (KMT2B) Protein Lysine Methyltransferase.Life (Basel). 2021 Aug 12;11(8):823. doi: 10.3390/life11080823. Life (Basel). 2021. PMID: 34440566 Free PMC article. Review.
-
Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome.Nat Genet. 2010 Sep;42(9):790-3. doi: 10.1038/ng.646. Epub 2010 Aug 15. Nat Genet. 2010. PMID: 20711175 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Miscellaneous
