Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 May-Jun;34(3):283-8.
doi: 10.1093/alcalc/34.3.283.

Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice

J Broadbent  1 , A Z Weitemier
Affiliations

Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice

J Broadbent et al. Alcohol Alcohol. 1999 May-Jun.

Abstract

DBA/2J mice repeatedly exposed to ethanol (2 g/kg, i.p. every 48 h for 8 days) exhibit sensitization to the locomotor stimulant effects of ethanol. Pretreatment with the NMDA receptor antagonist dizocilpine (0.2-0.3 mg/kg, i.p.) completely prevents the development of sensitization. Thus, NMDA receptors appear to play an important role in behavioural sensitization to ethanol.

PubMed Disclaimer

Publication types

LinkOut - more resources