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. 1999 Jun 29:877:751-5.
doi: 10.1111/j.1749-6632.1999.tb09316.x.

Changes in nociceptive and anxiolytic responses following herpes virus-mediated preproenkephalin overexpression in rat amygdala are naloxone-reversible and transient

W Kang  1 , S P Wilson, M A Wilson
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Changes in nociceptive and anxiolytic responses following herpes virus-mediated preproenkephalin overexpression in rat amygdala are naloxone-reversible and transient

W Kang et al. Ann N Y Acad Sci. .

Abstract

These results using herpes virus-mediated gene transfer to overexpress enkephalin in the amygdala support the role of amygdalar opioids in the anxiolytic actions of benzodiazepines and supraspinal nociception (see ref. 1). These studies also demonstrate the usefulness of recombinant herpes virus in evaluating the role of single gene products within specific brain sites in pharmacological responses and complex behaviors.

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