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Review
. 1999 Aug;67(8):3703-13.
doi: 10.1128/IAI.67.8.3703-3713.1999.

Host-pathogen interactions: redefining the basic concepts of virulence and pathogenicity

A Casadevall  1 , L A Pirofski
Affiliations
Review

Host-pathogen interactions: redefining the basic concepts of virulence and pathogenicity

A Casadevall et al. Infect Immun. 1999 Aug.
No abstract available

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Figures

FIG. 1
FIG. 1
Six damage-response curves representing six classes of microbial pathogens. The y axis denotes the amount of damage to the host resulting from the host-pathogen interaction. The x axis denotes the magnitude of the host immune response. Variable refers to the fact that the amount of damage can vary depending on the individual host.
FIG. 2
FIG. 2
Examples of how the damage-response curves for five pathogens can be altered by medical interventions. Details of each intervention are discussed in the text.
See this image and copyright information in PMC

References

    1. Allen J E, Maizels R M. Th1-Th2: reliable paradigm or dangerous dogma. Immunol Today. 1997;18:387–392. - PubMed
    1. Armstrong D. History of opportunistic infection in the immunocompromised host. Clin Infect Dis. 1993;17(Suppl. 2):S318–S321. - PubMed
    1. Brubaker R R. Mechanisms of bacterial virulence. Annu Rev Microbiol. 1985;39:21–50. - PubMed
    1. Deitsch K W, Moxon E R, Wellems T E. Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections. Microbiol Mol Biol Rev. 1997;61:281–293. - PMC - PubMed
    1. Dubos R J. The bacterial cell. London, United Kingdom: Harvard University Press; 1945. pp. 188–228.

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