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. 1999 Aug 1;341 ( Pt 3)(Pt 3):665-8.

APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase

Z Ahmed  1 , B J Smith, K Kotani, P Wilden, T S Pillay
Affiliations

APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase

Z Ahmed et al. Biochem J. .

Abstract

APS (adapter protein with a PH and SH2 domain) is the newest member of a family of tyrosine kinase adapter proteins including SH2-B and Lnk. We previously identified SH2-B as an insulin-receptor-binding protein and substrate [Kotani, Wilden and Pillay (1998) Biochem J. 335, 103-109]. Here we show that APS interacts with the insulin receptor kinase activation loop through its SH2 domain and insulin stimulates the tyrosine-phosphorylation of APS. Furthermore, the phosphorylation of activation-loop tyrosine residues 1158 and 1162 are required for this interaction.

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