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Case Reports
. 1999 Jul;116(1):253-5.
doi: 10.1378/chest.116.1.253.

Wegener's granulomatosis and alpha1-antitrypsin-deficiency emphysema: proteinase-related diseases

V T Barnett  1 , M Sekosan, A Khurshid
Affiliations
Case Reports

Wegener's granulomatosis and alpha1-antitrypsin-deficiency emphysema: proteinase-related diseases

V T Barnett et al. Chest. 1999 Jul.

Abstract

Wegener's granulomatosis (WG) and alpha1-antitrypsin (alpha1-AT)-deficiency emphysema are both uncommon disorders. A relationship may exist between these diseases involving the proteinase and antiproteinase balance in the lung. A case is presented of WG and alpha1-AT-deficiency emphysema occurring in the same patient. Previous studies concerning the correlation between abnormal alpha1-AT alleles and WG are discussed. Potential mechanisms for the relationship and recommendations for screening are given.

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