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Review
. 1999 Apr;4(2):213-20.
doi: 10.1023/a:1018733426625.

Programmed cell death in the terminal endbud

R C Humphreys  1
Affiliations
Review

Programmed cell death in the terminal endbud

R C Humphreys. J Mammary Gland Biol Neoplasia. 1999 Apr.

Abstract

Ductal development in the pubertal mouse mammary gland is characterized by dramatic morphological changes in the epithelium driven by proliferation of cap and body cells in the terminal endbuds. Recent experiments revealed a coincident and abundant apoptosis in the body cells of these structures. The cells undergoing apoptosis are occasionally restricted to defined regions within the terminal endbud. Localization adjacent to the presumptive lumina suggests that this process functions to sculpt the lumina of the subtending duct. Members of the Bcl-2 family of apoptosis regulatory molecules; Bcl-2 and Bcl-x, appear to have some role in regulating apoptosis in the terminal endbud. Other possible signals which could regulate this developmental process and a model are presented.

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