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. 1999 Jul 30;285(5428):754-6.
doi: 10.1126/science.285.5428.754.

Embryonic stem cell-derived glial precursors: a source of myelinating transplants

O Brüstle  1 , K N Jones, R D Learish, K Karram, K Choudhary, O D Wiestler, I D Duncan, R D McKay
Affiliations

Embryonic stem cell-derived glial precursors: a source of myelinating transplants

O Brüstle et al. Science. .

Abstract

Self-renewing, totipotent embryonic stem (ES) cells may provide a virtually unlimited donor source for transplantation. A protocol that permits the in vitro generation of precursors for oligodendrocytes and astrocytes from ES cells was devised. Transplantation in a rat model of a human myelin disease shows that these ES cell-derived precursors interact with host neurons and efficiently myelinate axons in brain and spinal cord. Thus, ES cells can serve as a valuable source of cell type-specific somatic precursors for neural transplantation.

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  • Stem cells as potential nerve therapy.
    Steghaus-Kovac S. Steghaus-Kovac S. Science. 1999 Jul 30;285(5428):650-1. doi: 10.1126/science.285.5428.650b. Science. 1999. PMID: 10454911 No abstract available.

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