Effect of diethylstilbestrol on reproductive function

Abstract

Objective: To review the effects of in utero exposure to diethylstilbestrol (DES) on müllerian development and subsequent reproductive function.

Design: The literature on DES and reproductive function was reviewed and summary data are presented. The studies were identified through the computerized MEDLINE database and a manual search of relevant bibliographies.

Result(s): In utero exposure to DES resulted in reduced fertility and increased rates of ectopic pregnancy, spontaneous abortion, and preterm delivery.

Conclusion(s): An understanding of the reproductive performance of women who were exposed to DES in utero is useful for counseling these patients regarding their risks and treatment options.