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. 1999 Aug 3;96(16):8825-6.
doi: 10.1073/pnas.96.16.8825.

Functional genomics

S Fields  1 , Y Kohara, D J Lockhart
Affiliations

Functional genomics

S Fields et al. Proc Natl Acad Sci U S A. .

Abstract

Complete genome sequences are providing a framework to allow the investigation of biological processes by the use of comprehensive approaches. Genome analysis also is having a dramatic impact on medicine through its identification of genes and mutations involved in disease and the elucidation of entire microbial gene sets. Studies of the sequences of model organisms, such as that of the nematode worm Caenorhabditis elegans, are providing extraordinary insights into development and differentiation that aid the study of these processes in humans. The field of functional genomics seeks to devise and apply technologies that take advantage of the growing body of sequence information to analyze the full complement of genes and proteins encoded by an organism.

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Figures

Figure 1
Figure 1
Fluorescence image of an array that contains more than 280,000 different 25-mer oligonucleotide probes in an area of 1.28 × 1.28 cm. The array contains probe sets for more than 6,800 human genes, and the image was obtained after overnight hybridization of an amplified and labeled human mRNA sample.
See this image and copyright information in PMC

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