17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes
- PMID: 10431140
- DOI: 10.1677/jme.0.0230001
17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes
Abstract
A number of enzymes possessing 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (17HSD/KSR) activities have been described and cloned, but their nomenclature needs specification. To clarify the present situation, descriptions of the eight cloned 17HSD/KSRs are given and guidelines for the classification of novel 17HSD/KSR enzymes are presented.
Similar articles
-
Androgenic and estrogenic 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase in human ovarian epithelial tumors: evidence for the type 1, 2 and 5 isoforms.J Steroid Biochem Mol Biol. 2002 Aug;81(4-5):343-51. doi: 10.1016/s0960-0760(02)00117-6. J Steroid Biochem Mol Biol. 2002. PMID: 12361724
-
A useful cell system for studying the regulation of 17HSD/KSR type 2 activity and expression in ovarian epithelial cancer.J Steroid Biochem Mol Biol. 2010 Oct;122(4):295-301. doi: 10.1016/j.jsbmb.2010.06.008. Epub 2010 Jun 17. J Steroid Biochem Mol Biol. 2010. PMID: 20600897
-
Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat.Mol Endocrinol. 1998 Jul;12(7):1048-59. doi: 10.1210/mend.12.7.0134. Mol Endocrinol. 1998. PMID: 9658408
-
Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5.Mol Cell Endocrinol. 2006 Mar 27;248(1-2):38-46. doi: 10.1016/j.mce.2005.11.035. Epub 2006 Feb 15. Mol Cell Endocrinol. 2006. PMID: 16480815 Review.
-
Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action.Mol Cell Endocrinol. 2001 Jan 22;171(1-2):211-5. doi: 10.1016/s0303-7207(00)00414-7. Mol Cell Endocrinol. 2001. PMID: 11165032 Review.
Cited by
-
The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells.PLoS One. 2012;7(1):e29835. doi: 10.1371/journal.pone.0029835. Epub 2012 Jan 9. PLoS One. 2012. PMID: 22253796 Free PMC article.
-
The Steroid Metabolome in the Isolated Ovarian Follicle and Its Response to Androgen Exposure and Antagonism.Endocrinology. 2017 May 1;158(5):1474-1485. doi: 10.1210/en.2016-1851. Endocrinology. 2017. PMID: 28323936 Free PMC article.
-
Susceptibility to Colorectal Cancer Based on HSD17B4 rs721673 and rs721675 Polymorphisms and Alcohol Intake among Taiwan Biobank Participants: A Retrospective Case Control Study Using the Nationwide Claims Data.J Pers Med. 2023 Mar 24;13(4):576. doi: 10.3390/jpm13040576. J Pers Med. 2023. PMID: 37108962 Free PMC article.
-
17beta-Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer.Br J Cancer. 2005 Feb 14;92(3):547-52. doi: 10.1038/sj.bjc.6602375. Br J Cancer. 2005. PMID: 15685233 Free PMC article.
-
Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk.Gynecol Oncol. 2011 Apr;121(1):54-8. doi: 10.1016/j.ygyno.2010.11.014. Epub 2010 Dec 3. Gynecol Oncol. 2011. PMID: 21129770 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources