Review
doi: 10.1016/s0167-5699(99)01488-7.
CTL granules: evolution of vesicles essential for combating virus infections
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- PMID: 10431154
- DOI: 10.1016/s0167-5699(99)01488-7
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Review
CTL granules: evolution of vesicles essential for combating virus infections
Immunol Today.
1999 Aug.
Abstract
Viral strategies for escaping apoptosis have co-evolved with the immune system, resulting in a complex balance of pro- and anti-apoptotic forces in virus-infected cells under attack by cytotoxic T lymphocytes (CTLs). Here, Joseph Trapani and colleagues argue that CTL cytolytic granules are the principal apoptotic means of eliminating viruses and possess multiple independent mechanisms to counter the viral anti-apoptotic machinery.
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