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Review
. 1999 Aug;20(8):375-82.
doi: 10.1016/s0167-5699(99)01484-x.

The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

M L Lupher Jr  1 , N Rao, M J Eck, H Band
Affiliations
Review

The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

M L Lupher Jr et al. Immunol Today. 1999 Aug.

Abstract

The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.

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