Review
doi: 10.1016/s0168-9525(99)01782-5.
Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes
Affiliations
- PMID: 10431187
- DOI: 10.1016/s0168-9525(99)01782-5
Item in Clipboard
Review
Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes
Trends Genet.
1999 Aug.
Abstract
Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory response in the normal host. Through genetic analysis of mutant mice, the gene encoding Toll-like receptor 4 (Tlr4) was recently identified as a critical component of this host defense mechanism. Tlr4 is a member of an ancient gene family that regulates antimicrobial host defense in plants, invertebrates and mammals.
Similar articles
-
Critical roles of Toll-like receptors in host defense.Crit Rev Immunol. 2000;20(5):393-405. Crit Rev Immunol. 2000. PMID: 11145217 Review.
-
Toll and Toll-like proteins: an ancient family of receptors signaling infection.Rev Immunogenet. 2000;2(3):294-304. Rev Immunogenet. 2000. PMID: 11256741 Review.
-
Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity.Curr Opin Microbiol. 2000 Feb;3(1):23-8. doi: 10.1016/s1369-5274(99)00046-6. Curr Opin Microbiol. 2000. PMID: 10679425 Review.
-
Innate immune sensing of microbial infection: the mechanism and the therapeutic challenge.Wien Med Wochenschr. 2002;152(21-22):547-51. doi: 10.1046/j.1563-258x.2002.02097.x. Wien Med Wochenschr. 2002. PMID: 12506676 Review.
-
Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders.Curr Opin Microbiol. 2002 Feb;5(1):70-5. doi: 10.1016/s1369-5274(02)00288-6. Curr Opin Microbiol. 2002. PMID: 11834372 Review.
Cited by
-
Murine retroviruses activate B cells via interaction with toll-like receptor 4.Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2281-6. doi: 10.1073/pnas.042355399. Proc Natl Acad Sci U S A. 2002. PMID: 11854525 Free PMC article.
-
Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains.Infect Immun. 2002 Apr;70(4):1997-2009. doi: 10.1128/IAI.70.4.1997-2009.2002. Infect Immun. 2002. PMID: 11895964 Free PMC article.
-
Differential expression of toll-like receptor 3 and 5 in ileal pouch mucosa of ulcerative colitis patients.Int J Colorectal Dis. 2007 Mar;22(3):293-301. doi: 10.1007/s00384-006-0133-6. Epub 2006 Jun 13. Int J Colorectal Dis. 2007. PMID: 16770571
-
Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats.Mol Pain. 2017 Jan;13:1744806916688901. doi: 10.1177/1744806916688901. Mol Pain. 2017. PMID: 28326931 Free PMC article.
-
Direct evidence for involvement of NF-kappaB in transcriptional activation of tumor necrosis factor by a spirochetal lipoprotein.Infect Immun. 2000 Sep;68(9):5447-9. doi: 10.1128/IAI.68.9.5447-5449.2000. Infect Immun. 2000. PMID: 10948181 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
