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. 1999 Aug 15;342 ( Pt 1)(Pt 1):7-12.

DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

S Dowler  1 , R A Currie, C P Downes, D R Alessi
Affiliations

DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

S Dowler et al. Biochem J. .

Abstract

We have identified a novel 280 amino acid protein which contains a putative myristoylation site at its N-terminus followed by an Src homology (SH2) domain and a pleckstrin homology (PH) domain at its C-terminus. It has been termed dual adaptor for phosphotyrosine and 3-phosphoinositides (DAPP1). DAPP1 is widely expressed and exhibits high-affinity interactions with PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2), but not with other phospholipids tested. These observations predict that DAPP1 will interact with both tyrosine phosphorylated proteins and 3-phosphoinositides and may therefore play a role in regulating the location and/or activity of such proteins(s) in response to agonists that elevate PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2).

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