Sleep and serotonin: an unfinished story
- PMID: 10432485
- DOI: 10.1016/S0893-133X(99)00009-3
Sleep and serotonin: an unfinished story
Abstract
Serotonin (5-HT) was first believed to be a true neuromodulator of sleep because the destruction of 5-HT neurons of the raphe system or the inhibition of 5-HT synthesis with p-chlorophenylalanine induced a severe insomnia which could be reversed by restoring 5-HT synthesis. However the demonstration that the electrical activity of 5-HT perikarya and the release of 5-HT are increased during waking and decreased during sleep was in direct contradiction to this hypothesis. More recent experiments suggest that the release of 5-HT during waking may initiate a cascade of genomic events in some hypnogenic neurons located in the preoptic area. Thus, when 5-HT is released during waking, it leads to an homeostatic regulation of slow-wave sleep.
Similar articles
-
Serotoninergic mechanisms and sleep.J Physiol (Paris). 1981;77(2-3):415-24. J Physiol (Paris). 1981. PMID: 6457142 Review.
-
The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies.Neuropsychopharmacology. 1990 Feb;3(1):41-50. Neuropsychopharmacology. 1990. PMID: 2137698
-
Serotonin control of sleep-wake behavior.Sleep Med Rev. 2011 Aug;15(4):269-81. doi: 10.1016/j.smrv.2010.11.003. Epub 2011 Apr 2. Sleep Med Rev. 2011. PMID: 21459634 Review.
-
Modulation of serotonergic projection from dorsal raphe nucleus to basolateral amygdala on sleep-waking cycle of rats.Brain Res. 2002 Jul 26;945(1):60-70. doi: 10.1016/s0006-8993(02)02625-2. Brain Res. 2002. PMID: 12113952
-
The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep.Sleep Med Rev. 2010 Oct;14(5):319-27. doi: 10.1016/j.smrv.2009.10.003. Epub 2010 Feb 12. Sleep Med Rev. 2010. PMID: 20153670 Review.
Cited by
-
Serotonergic system in vivo with [11C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients.Sci Rep. 2022 Apr 15;12(1):6292. doi: 10.1038/s41598-022-10067-5. Sci Rep. 2022. PMID: 35428769 Free PMC article.
-
Modulating role of serotonergic signaling in sleep and memory.Pharmacol Rep. 2022 Feb;74(1):1-26. doi: 10.1007/s43440-021-00339-8. Epub 2021 Nov 6. Pharmacol Rep. 2022. PMID: 34743316 Review.
-
Serotonin modulates infraslow oscillation in the dentate gyrus during non-REM sleep.Elife. 2025 Apr 3;13:RP100196. doi: 10.7554/eLife.100196. Elife. 2025. PMID: 40178074 Free PMC article.
-
Conservation of sleep: insights from non-mammalian model systems.Trends Neurosci. 2008 Jul;31(7):371-6. doi: 10.1016/j.tins.2008.05.001. Epub 2008 Jun 5. Trends Neurosci. 2008. PMID: 18538867 Free PMC article. Review.
-
Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors.PLoS Genet. 2022 Nov 21;18(11):e1010289. doi: 10.1371/journal.pgen.1010289. eCollection 2022 Nov. PLoS Genet. 2022. PMID: 36409783 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
