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. 1999 Apr-May;18(4-5):891-2.
doi: 10.1080/15257779908041594.

Anti-HIV-1 activities of 1,3-dioxolane guanine and 2,6-diaminopurine dioxolane

Z Gu  1 , M A Wainberg, P Nguyen-Ba, L L'Heureux, J M de Muys, R F Rando
Affiliations

Anti-HIV-1 activities of 1,3-dioxolane guanine and 2,6-diaminopurine dioxolane

Z Gu et al. Nucleosides Nucleotides. 1999 Apr-May.

Abstract

DXG and its prodrug DAPD have been demonstrated to be effective inhibitors of HIV-1 in various cells. The EC50s for DXG were 0.032 microM in CBMCs and 0.05 microM in MT-4 cells, which were generally equipotent as 3TC. 3TC-resistant, but not AZT-resistant, HIV-1 had minimum diminished sensitivity to the compounds. Both DXG and DAPD were non-toxic to cells up to 500 microM.

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