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. 1999 Feb;20(2):167-70.

Effect of dexamethasone on cardiovascular response induced by norepinephrine in nucleus tractus solitarii

M Ou-Yang  1 , G H Ge, S Wang
Affiliations
  • PMID: 10437166
Free article

Effect of dexamethasone on cardiovascular response induced by norepinephrine in nucleus tractus solitarii

M Ou-Yang et al. Zhongguo Yao Li Xue Bao. 1999 Feb.
Free article

Abstract

Aim: To study the effect of dexamethasone on cardiovascular response induced by norepinephrine (NE) in nucleus tractus solitarii (NTS).

Methods: The variations of cardiovascular action caused by these drugs were observed after injection of mifepristone (Mif), dexamethasone (Dex), bicuculline (Bic), and NE into the medial and intermediate NTS.

Results: Microinjection of Dex (0.39 mmol.L-1, 0.1 microL) into the medial and intermediate NTS abolished the vasodepressed response to NE (8 mmol.L-1, 0.1 microL) microinjected into the same area 10 min later, and the inhibition did not disappear until 4 h. The rapid inhibitory effects of Dex on NE vasodepression was not antagonized by Mif (4.66 mumol.L-1, 0.1 microL), but it was blocked by Bic (3.24 mumol.L-1, 0.1 microL).

Conclusion: Dex abolished cardiovascular response to NE microinjected into NTS which may be mediated by GABAA receptor.

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