Poliovirus infection induces apoptosis in CaCo-2 cells

Abstract

The effects of poliovirus infection in CaCo-2 cells, a human enterocyte-like cell line are described. Infected cells were examined by a combination of techniques, including optical and electron microscopy, cytofluorimetric analysis of DNA content, and DNA agarose gel electrophoresis. Results obtained by the different experimental approaches demonstrate that poliovirus infection in enterocyte-like cells can result in an apoptotic process.