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Review
. 1978 Aug:15 Suppl 5:51-87.
doi: 10.1177/0300985878015s0507.

Heavy metal nephropathy of rodents

B J Payne, L Z Saunders
Review

Heavy metal nephropathy of rodents

B J Payne et al. Vet Pathol. 1978 Aug.

Abstract

Heavy metal nephropathy is a pathologic entity of the renal tubular epithelium of rats, evoked by lead, gold, and other heavy metals. It is characterized acutely by coagulative necrosis, subacutely by cortical fibrosis, and chronically by cytomegaly and karyomegaly. Finally, adenomas develop, some of which become malignant.

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