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Review
. 1999 Aug;9(4):428-32.
doi: 10.1016/S0959-440X(99)80059-1.

Interfacial binding of secreted phospholipases A(2): more than electrostatics and a major role for tryptophan

M H Gelb  1 , W Cho, D C Wilton
Affiliations
Review

Interfacial binding of secreted phospholipases A(2): more than electrostatics and a major role for tryptophan

M H Gelb et al. Curr Opin Struct Biol. 1999 Aug.

Abstract

Secreted phospholipases A(2) have similar catalytic sites, but vastly different interfacial binding surfaces that modulate their binding affinity for different kinds of phospholipid vesicles by several orders of magnitude. The structure/function principles that dictate both the differential interfacial binding and the physiological function of these enzymes are beginning to be unraveled.

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