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. 1999 Sep;37(9):3013-6.
doi: 10.1128/JCM.37.9.3013-3016.1999.

Hepatitis B virus (HBV) mutations associated with resistance to lamivudine in patients coinfected with HBV and human immunodeficiency virus

V Thibault  1 , Y Benhamou, C Seguret, M Bochet, C Katlama, F Bricaire, P Opolon, T Poynard, H Agut
Affiliations

Hepatitis B virus (HBV) mutations associated with resistance to lamivudine in patients coinfected with HBV and human immunodeficiency virus

V Thibault et al. J Clin Microbiol. 1999 Sep.

Abstract

Mutations associated with hepatitis B virus (HBV) resistance to lamivudine have not been extensively addressed in human immunodeficiency virus (HIV)-HBV coinfection. We have studied the HBV polymerase sequences from nine coinfected patients who experienced HBV recurrence while under lamivudine treatment. In seven of these nine patients, Met(550), belonging to the highly conserved YMDD motif, was mutated to Val and was associated with a substitution of Met for Leu(526) in each case. In the two remaining patients, we found a Met(550)-to-Ile change that was associated in only one case with a Leu(526)-to-Met mutation. No mutation was observed in three control patients not receiving lamivudine. This study demonstrates the emergence of particular genetic profiles in HBV-HIV-coinfected patients experiencing a loss of control of HBV infection despite high doses of lamivudine.

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Figures

FIG. 1
FIG. 1
Course of HBV DNA during lamivudine treatment and resistance occurrence. HBV DNA from each of nine patients was measured at different time points and is represented by a specific dot. The time point of sequence analysis is represented by an arrowhead above each graph with the position of each residue.
See this image and copyright information in PMC

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References

    1. Allen M I, Deslauriers M, Andrews C W, Tipples G A, Walters K A, Tyrrell D L, Brown N, Condreay L D. Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group. Hepatology. 1998;27:1670–1677. - PubMed
    1. Aye T T, Bartholomeusz A, Shaw T, Bowden S, Breschkin A, McMillan J, Angus P, Locarnini S. Hepatitis B virus polymerase mutations during antiviral therapy in a patient following liver transplantation. J Hepatol. 1997;26:1148–1153. - PubMed
    1. Back N K, Nijhuis M, Keulen W, Boucher C A, Oude Essink B O, van Kuilenburg A B, van Gennip A H, Berkhout B. Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme. EMBO J. 1996;15:4040–4049. - PMC - PubMed
    1. Bartholomew M M, Jansen R W, Jeffers L J, Reddy K R, Johnson L C, Bunzendahl H, Condreay L D, Tzakis A G, Schiff E R, Brown N A. Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation. Lancet. 1997;349:20–22. - PubMed
    1. Benhamou Y, Katlama C, Lunel F, Coutellier A, Dohin E, Hamm N, Tubiana R, Herson S, Poynard T, Opolon P. Effects of lamivudine on replication of hepatitis B virus in HIV-infected men. Ann Intern Med. 1996;125:705–712. - PubMed