Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Aug 17;96(17):9457-8.
doi: 10.1073/pnas.96.17.9457.

Homosynaptic long-term depression: a mechanism for memory?

M F Bear  1
Affiliations
Review

Homosynaptic long-term depression: a mechanism for memory?

M F Bear. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
A potential mechanism for the facilitation of LTD by novelty. Manahan-Vaughan and Braunewell (1) report that exposing a rat to a novel environment produces a striking facilitation of homosynaptic LTD in vivo. Similar to the effect of novelty exposure, transient application of carbachol, an analogue of ACh, enables induction of LTD in visual cortex and hippocampus by synaptic stimulation that is normally without effect. This figure is modified, with permission, from ref. .
See this image and copyright information in PMC

Comment on

References

    1. Manahan-Vaughan D, Braunewell K-H. Proc Natl Acad Sci USA. 1999;96:8739–8744. - PMC - PubMed
    1. Lømo T. Acta Physiol Scand. 1966;68:128.
    1. Bliss T V P, Lømo T. J Physiol (London) 1973;232:331–356. - PMC - PubMed
    1. Bliss T V, Gardner-Medwin A R. J Physiol (London) 1971;216:32P–33P. - PubMed
    1. Schwartzkroin P A, Wester K. Brain Res. 1975;89:107–119. - PubMed