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Comparative Study
. 1999 Mar;52(3):234-6.
doi: 10.1136/jcp.52.3.234.

Telomerase expression in intracranial tumours: prognostic potential for malignant gliomas and meningiomas

M L Falchetti  1 , R Pallini, L M Larocca, R Verna, E D'Ambrosio
Affiliations
Comparative Study

Telomerase expression in intracranial tumours: prognostic potential for malignant gliomas and meningiomas

M L Falchetti et al. J Clin Pathol. 1999 Mar.

Abstract

Aim: To evaluate the diagnostic value of telomerase expression in intracranial tumours.

Methods: 98 surgical specimens from different neoplasms were analysed by the telomeric repeat amplification protocol (TRAP) and the presence of telomerase compared with the histological diagnosis and the proliferation index.

Results: A high degree of positivity for telomerase activity was found in glioblastomas and atypical/anaplastic meningiomas. Telomerase activity was poorly detected in anaplastic astrocytomas.

Conclusions: The TRAP assay seems to be a valuable index for identifying meningeal tumours with aggressive behaviour.

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