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. 1999 Jul;48(7):399-403.
doi: 10.1007/s000110050478.

Effect of hydrogen peroxide on the metabolism of articular chondrocytes

S Asada  1 , K Fukuda, M Oh, C Hamanishi, S Tanaka
Affiliations

Effect of hydrogen peroxide on the metabolism of articular chondrocytes

S Asada et al. Inflamm Res. 1999 Jul.

Abstract

Objective: To examine the effect of hydrogen peroxide on chondrocyte metabolism.

Materials and methods: Bovine articular chondrocytes were used. Proteoglycan (PG) synthesis was measured with [35S] sulfate incorporation. For detection of apoptosis, the TdT-mediated dUTP-biotin nick end labeling (TUNEL) and annexin V assay were used. Extracellular-regulated protein kinase (ERK) activity was measured using a mitogen-activated protein kinase assay system.

Results: Addition of hydrogen peroxide resulted in the inhibition of PG synthesis, apoptosis, and enhanced ERK activity.

Conclusion: Hydrogen peroxide plays an important role in regulating the metabolism of chondrocytes.

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