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Editorial
. 1999 Sep;189(1):1-3.
doi: 10.1002/(SICI)1096-9896(199909)189:1<1::AID-PATH432>3.0.CO;2-P.

Do HPV-negative cervical carcinomas exist?--revisited

C S Herrington
Editorial

Do HPV-negative cervical carcinomas exist?--revisited

C S Herrington. J Pathol. 1999 Sep.

Abstract

There has been considerable debate regarding the existence of HPV-negative cervical carcinoma. In this issue of the journal, using well-controlled methodology, Walboomers et al. demonstrate that HPV DNA is present in almost all invasive carcinomas in a large multinational study. This indicates that HPV-negative carcinoma is extremely uncommon, if it exists at all. It also implies that HPV testing, if optimally applied, is capable of a sensitivity approaching 100 per cent. This has significant implications for cervical screening.

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