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. 1999 Aug;8(8):1708-10.
doi: 10.1110/ps.8.8.1708.

p53 Family members p63 and p73 are SAM domain-containing proteins

C D Thanos  1 , J U Bowie
Affiliations

p53 Family members p63 and p73 are SAM domain-containing proteins

C D Thanos et al. Protein Sci. 1999 Aug.

Abstract

Homologs of the tumor suppressor p53, called p63 and p73, have been identified. The p63 and p73 family members possess a domain structure similar to p53, but contain variable C-terminal extensions. We find that some of the C-terminal extensions contain Sterile Alpha Motif (SAM) domains. SAM domains are protein modules that are involved in protein-protein interactions. Consistent with this role, the C-terminal SAM domains of the p63 and p73 may regulate function by recruiting other protein effectors.

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