Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Aug 21;319(7208):508-12.
doi: 10.1136/bmj.319.7208.508.

Methods in health service research. An introduction to bayesian methods in health technology assessment

Affiliations
Review

Methods in health service research. An introduction to bayesian methods in health technology assessment

D J Spiegelhalter et al. BMJ. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Prior (a), likelihood (b), and posterior (c) distributions arising from reanalysis by Pocock and Spiegelhalter of the GREAT trial of home thrombolysis. The prior distribution represents a summary of evidence external to the trial, the likelihood expresses evidence from the trial itself, and the posterior distribution pools these two sources by multiplying the two curves together
Figure 2
Figure 2
Prior, likelihood, and posterior distributions arising from Cancer and Leukaemia Group B trial of standard radiotherapy versus additional chemotherapy in advanced lung cancer. Dashed lines give boundaries of range of clinical equivalence, taken to be 0 and 4 months median improvement in survival. Numbers by each graph show probabilities of lying below, within, and above the range of equivalence
Figure 3
Figure 3
Traditional and bayesian estimates of standardised treatment effects in a randomised trial of treatments for cancer. The bayesian estimates are pulled towards the overall treatment effect by a degree determined by the empirical heterogeneity of the subset results

Comment in

References

    1. Kadane JB. Prime time for Bayes. Contr Clin Trials. 1995;16:313–318. - PubMed
    1. Breslow N. Biostatistics and Bayes. Stat Sci. 1990;5:269–284.
    1. Lilford RJ, Braunholtz D. The statistical basis of public policy—a paradigm shift is overdue. BMJ. 1996;313:603–607. - PMC - PubMed
    1. Berry DA, Stangl DK. Bayesian biostatistics. New York: Dekker; 1996.
    1. Eddy DM, Hasselblad V, Shachter R. Meta-analysis by the confidence profile method: the statistical synthesis of evidence. San Diego, CA: Academic; 1992.