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. 1999 Aug;38(16):2411-2413.
doi: 10.1002/(sici)1521-3773(19990816)38:16<2411::aid-anie2411>3.0.co;2-t.

The First General Method for Stille Cross-Couplings of Aryl Chlorides

AF Littke  1 , GC Fu
Affiliations

The First General Method for Stille Cross-Couplings of Aryl Chlorides

AF Littke et al. Angew Chem Int Ed Engl. 1999 Aug.

Abstract

A "one-two punch" comprising two commercially available reagents, PtBu(3) and CsF, provides a practical and general solution for a long-standing limitation of the Stille reaction-the inability to couple inexpensive and readily available aryl chlorides [Eq. (1); R(1)=OMe, NH(2), o-Me, etc.; R=vinyl, allyl, Ph, Bu, etc.].

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