Review
doi: 10.1016/s1369-5274(99)80071-x.
Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis
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- PMID: 10458986
- DOI: 10.1016/s1369-5274(99)80071-x
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Review
Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis
Curr Opin Microbiol.
1999 Aug.
Abstract
A general association of human and primate lymphotropic herpesviruses (gamma-herpesviruses) with the development of lymphomas, as well as other tumors, especially in immunocompromised hosts, has been well documented. The lack of relevant small animal models for human gamma-herpesviruses has impeded progress in understanding the role of these viruses in the development of chronic disease. Recent research characterizing infection of inbred strains of mice with a murine gamma-herpesvirus, gamma-herpesvirus 68 (gammaHV68), is providing insights into viral and host factors involved in the establishment and control of chronic gamma-herpesvirus infection.
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