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Review
. 1999 Aug 23;146(4):703-8.
doi: 10.1083/jcb.146.4.703.

Extranuclear apoptosis. The role of the cytoplasm in the execution phase

J C Mills  1 , N L Stone, R N Pittman
Affiliations
Review

Extranuclear apoptosis. The role of the cytoplasm in the execution phase

J C Mills et al. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
Scheme for temporal and mechanistic organization of the cytoplasmic execution phase. (Top) Morphological view. (Bottom) Corresponding actin rearrangements.
Figure 2
Figure 2
Model for bleb extrusion. Contraction of cortical actin filaments by myosin II causes contraction of plasma membrane, except in focal regions of weakness in actin links to the membrane. Such regions of weakness can be caused by cleavage of membrane-anchoring proteins (e.g., fodrin). The combination of contraction and focal loss of membrane support leads to bleb formation.
Figure 3
Figure 3
Possible altruistic role of apoptosis in epithelial cells. The same actomyosin contractile forces that cause blebbing can pull neighboring cells to cover potential gaps in the monolayer and maintain barrier function.
See this image and copyright information in PMC

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