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Clinical Trial
. 1999 Aug 15;46(4):581-4.
doi: 10.1016/s0006-3223(99)00102-x.

Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers

M Franklin  1 , J Chi, C McGavin, R Hockney, A Reed, G Campling, R W Whale, P J Cowen
Affiliations
Clinical Trial

Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers

M Franklin et al. Biol Psychiatry. .

Abstract

Background: We studied the effect of a single dose of a formulation of a methanolic extract of Hypericum perforatum (HP), also known as St. John's wort, on plasma concentrations of growth hormone (GH), prolactin (PRL), and cortisol (CORT) in 12 healthy male volunteers.

Methods: Subjects received 9 tablets of the finished product Jarsin 300 and placebo in a double-blind, balanced-order, cross-over design.

Results: Following HP relative to placebo, there was a significant increase in plasma GH and a significant decrease in plasma PRL. Plasma CORT levels were unchanged.

Conclusions: Taken together with data from animal experimental studies, the findings suggest that this dose of HP may increase some aspects of brain dopamine function in humans.

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