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Review
. 1999 Sep;17(9):347-51.
doi: 10.1016/s0167-7799(99)01348-7.

A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis

P F Davies  1 , D C Polacek, J S Handen, B P Helmke, N DePaola
Affiliations
Free article
Review

A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis

P F Davies et al. Trends Biotechnol. 1999 Sep.
Free article

Abstract

The initiation and progression of focal atherosclerotic lesions has long been known to be associated with regions of disturbed blood flow. Improved precision in experimental models of spatially defined flow has recently been combined with regional and single-cell gene-expression profiling to investigate the relationships linking haemodynamics to vessel-wall pathobiology.

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