doi: 10.1016/s0304-3940(99)00488-7.
Priming stimulation in the basolateral amygdala modulates synaptic plasticity in the rat dentate gyrus
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- PMID: 10462103
- DOI: 10.1016/s0304-3940(99)00488-7
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Priming stimulation in the basolateral amygdala modulates synaptic plasticity in the rat dentate gyrus
Neurosci Lett.
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Abstract
We investigated the effects of basolateral amygdala (BLA) priming on long-term potentiation (LTP) in the dentate gyrus (DG). In the control animals, the induction of high-frequency stimulation (HFS) to the perforant path (PP) resulted in hippocampal LTP at all the time intervals tested. A priming stimulation to the BLA prior to the application of HFS to the PP resulted in the enhancement of the excitatory post-synaptic potential (EPSP)-LTP and population spike (PS)-LTP in the DG from 90-min post-HFS onwards. These findings suggest that the amygdala has a potential role in the modulation of some aspects of memory that are mediated by the hippocampus.
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